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Blood, 1 May 2006, Vol. 107, No. 9, pp. 3724-3726. Prepublished online as a Blood First Edition Paper on December 20, 2005; DOI 10.1182/blood-2005-08-3453. This Article Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: 2005-08-3453v1 107/9/3724    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stirewalt, D. L Articles by Radich, J. P Search for Related Content PubMed PubMed Citation Articles by Stirewalt, D. L Articles by Radich, J. P Related Collections Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 26, 2005 Accepted November 19, 2005 Size of FLT3 internal tandem duplication has prognostic significance in patients with acute myeloid leukemia Derek L Stirewalt*, Kenneth J Kopecky, Soheil Meshinchi, Julia H Engel, Era L Pogosova-Agadjanyan, Jeremy Linsley, Marilyn L Slovak, Cheryl L Willman, and Jerald P Radich Clinical Research Division, Fred Hutchinson Cancer Research Center, and the Division of Oncology, University of Washington, Seattle, WA, USA Southwest Oncology Group Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA Clinical Research Division, Fred Hutchinson Cancer Research Center, and the Division of Oncology, University of Washington, Seattle, WA, USA; Department of Children's Oncology Group, Myeloid Disease Committee, Arcadia, CA, USA Department of Cytogenetics, City of Hope National Medical Center, Duarte, CA, USA Department of Pathology and Cell Biology, Univeristy of New Mexico School of Medicine, Albuquerque, NM, USA * Corresponding author; email: dstirewa{at}fhcrc.org. FLT3 internal tandem duplications (FLT3/ITDs) in the juxtamembrane domain are found in approximately 25% of acute myeloid leukemia (AML) patients, ranging in size from three to hundreds of nucleotides. We examined if the sizes of FLT3/ITDs were associated with clinical outcomes in 151 AML patients enrolled in Southwest Oncology Group studies: S9333 and S9500. FLT3/ITDs were identified in 32% of patients (median ITD size = 39 nucleotides, range 15 - 153). The CR rates were 35%, 67%, and 52% for patients with large (40), small (< 0) and no ITDs, respectively (p = 0.19). Increasing ITD size was associated with decreasing OS (estimated 5-year OS, large = 13%, small = 26%, and no ITD = 21%, p = 0.072) and RFS (estimated 5-year RFS, large = 13%, small = 27%, and no ITD = 34%, p = 0.017). These studies suggest that ITD size may have prognostic significance. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML) Rajko Kusec, Ozren Jaksic, Slobodanka Ostojic, Ika Kardum-Skelin, Radovan Vrhovac, Branimir Jaksic, and Derek L. Stirewalt Blood 2006 108: 405-406. [Full Text] [PDF] This article has been cited by other articles: S. Meshinchi, D. L. Stirewalt, T. A. Alonzo, T. J. Boggon, R. B. Gerbing, J. L. Rocnik, B. J. Lange, D. G. Gilliland, and J. P. Radich Structural and numerical variation of FLT3/ITD in pediatric AML Blood, May 15, 2008; 111(10): 4930 - 4933. [Abstract] [Full Text] [PDF] L. Bullinger, K. Dohner, R. Kranz, C. Stirner, S. Frohling, C. Scholl, Y. H. Kim, R. F. Schlenk, R. Tibshirani, H. Dohner, et al. An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML Blood, May 1, 2008; 111(9): 4490 - 4495. [Abstract] [Full Text] [PDF] R. E. Gale, C. Green, C. Allen, A. J. Mead, A. K. Burnett, R. K. Hills, D. C. Linch, and on behalf of the Medical Research Council Adult Le The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia Blood, March 1, 2008; 111(5): 2776 - 2784. [Abstract] [Full Text] [PDF] S. Vempati, C. Reindl, S. K. Kaza, R. Kern, T. Malamoussi, M. Dugas, G. Mellert, S. Schnittger, W. Hiddemann, and K. Spiekermann Arginine 595 is duplicated in patients with acute leukemias carrying internal tandem duplications of FLT3 and modulates its transforming potential Blood, July 15, 2007; 110(2): 686 - 694. [Abstract] [Full Text] [PDF] K. Mrozek, G. Marcucci, P. Paschka, S. P. Whitman, and C. D. Bloomfield Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? Blood, January 15, 2007; 109(2): 431 - 448. [Abstract] [Full Text] [PDF] C. H. Seedhouse, M. Pallis, M. Grundy, and N. Russell Increasing FLT3-ITD Length Increases Expression of bcl-xl in AML. Blood (ASH Annual Meeting Abstracts), November 16, 2006; 108(11): 1909 - 1909. [Abstract] [Full Text] [PDF] R. Kusec, O. Jaksic, S. Ostojic, I. Kardum-Skelin, R. Vrhovac, B. Jaksic, and D. L. Stirewalt More on prognostic significance of FLT3/ITD size in acute myeloid leukemia (AML). Blood, July 1, 2006; 108(1): 405 - 406. [Full Text] [PDF]

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