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Blood, 1 May 2006, Vol. 107, No. 9, pp. 3511-3519. Prepublished online as a Blood First Edition Paper on January 5, 2006; DOI 10.1182/blood-2005-08-3454. This Article Full Text (PDF) All Versions of this Article: 2005-08-3454v1 107/9/3511    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maillard, I. Articles by Pear, W. S Search for Related Content PubMed PubMed Citation Articles by Maillard, I. Articles by Pear, W. S Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 26, 2005 Accepted December 26, 2005 Notch-dependent T lineage commitment occurs at extrathymic sites following bone marrow transplantation Ivan Maillard, Benjamin A Schwarz, Arivazhagan Sambandam, Terry Fang, Olga Shestova, Lanwei Xu, Avinash Bhandoola, and Warren S Pear* Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA; Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA, USA * Corresponding author; email: wpear{at}mail.med.upenn.edu. Early T lineage progenitors (ETPs) arise after colonization of the thymus by multipotent bone marrow progenitors. ETPs likely serve as physiologic progenitors of T cell development in adult mice, although alternative T cell differentiation pathways may exist. While investigating mechanisms of T cell reconstitution after bone marrow transplantation (BMT), we found that efficient donor-derived thymopoiesis occurred before the pool of ETPs had been replenished. Simultaneously, T lineage restricted progenitors were generated at extrathymic sites, both in the spleen and in peripheral lymph nodes, but not in the bone marrow or liver. The generation of these T lineage-committed cells occurred through a Notch-dependent differentiation process. Multipotent bone marrow progenitors efficiently gave rise to extrathymic T lineage committed cells, while common lymphoid progenitors did not. Our data show plasticity of T lineage commitment sites in the post-BMT environment and indicate that Notch-driven extrathymic T lineage commitment from multipotent progenitors may contribute to early T lineage reconstitution after BMT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. A. Dudakov, G. L. Goldberg, J. J. Reiseger, K. Vlahos, A. P. Chidgey, and R. L. Boyd Sex Steroid Ablation Enhances Hematopoietic Recovery following Cytotoxic Antineoplastic Therapy in Aged Mice J. Immunol., December 1, 2009; 183(11): 7084 - 7094. [Abstract] [Full Text] [PDF] T. Hosoya, T. Kuroha, T. Moriguchi, D. Cummings, I. Maillard, K.-C. Lim, and J. D. Engel GATA-3 is required for early T lineage progenitor development J. Exp. Med., November 23, 2009; (2009) jem.20090934v1. [Abstract] [Full Text] [PDF] E. J. Volanakis, R. T. Williams, and C. J. 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