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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2766-2773. Prepublished online as a Blood First Edition Paper on January 5, 2006; DOI 10.1182/blood-2005-09-3578. This Article Full Text (PDF) All Versions of this Article: 2005-09-3578v1 107/7/2766    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dentali, F. Articles by Ageno, W. Search for Related Content PubMed PubMed Citation Articles by Dentali, F. Articles by Ageno, W. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 6, 2005 Accepted November 28, 2005 Thrombophilic abnormalities, oral contraceptives and risk of cerebral vein thrombosis: a meta-analysis Francesco Dentali, Mark Crowther*, and Walter Ageno Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Clinical Medicine, University of Insubria, Varese, Italy * Corresponding author; email: crowthrm{at}mcmaster.ca. Recent studies suggest that thrombophilic abnormalities and the use of oral contraceptives (OC) are the leading causes of cerebral vein thrombosis (CVT). To assess the association between CVT and thrombophilic states, OC and their interaction. The MEDLINE, EMBASE, Cochrane Library databases (January 1994 to March 2005), reference lists of retrieved articles and contact with content experts. Studies comparing the prevalence of OC use and the prevalence of prothrombitic abnormalities in patients with CVT compared with healthy controls. Two reviewers independently selected studies and extracted study characteristics, quality and outcomes. Odds Ratios were calculated for each trial and pooled using the Mantel-Haenszel method. Seventeen studies were included. There was an increased risk of CVT in patients using OC (OR, 5.59; 95% CI: 3.95 to 7.91; p< 0.0001), and in patients with factor V Leiden (OR; 3.38; 95% CI: 2.27 to 5.05; p< 0.00001), with mutation G20210A of prothrombin (OR 9.27; 95% CI: 5.85 to 14.67; p< 0.00001) and with hyperhomocysteinemia (OR, 4.07; 95% CI: 2.54 to 6.52; p< 0.00001). OC-users, and patients with factor V Leiden, the prothrombin G20120A mutation and hyperhomocysteinemia are at significantly increased risk of CVT. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Santoro A Woman With Rectal Sinus and Left Transversal Sinus Thrombosis After Ovarian Stimulation: Case Report Clinical and Applied Thrombosis/Hemostasis, December 1, 2009; 15(6): 711 - 713. [Abstract] [PDF] P. Dulicek, J. Maly, M. Pecka, M. Beranek, E. Cermakova, and R. Maly Venous Thromboembolism in Young Female While on Oral Contraceptives: High Frequency of Inherited Thrombophilia and Analysis of Thrombotic Events in 400 Czech Women Clinical and Applied Thrombosis/Hemostasis, October 1, 2009; 15(5): 567 - 573. [Abstract] [PDF] J. M. Coutinho, J. M. Ferro, P. Canhao, F. Barinagarrementeria, C. Cantu, M.-G. Bousser, and J. Stam Cerebral Venous and Sinus Thrombosis in Women Stroke, July 1, 2009; 40(7): 2356 - 2361. [Abstract] [Full Text] [PDF] I. Martinelli, M. Franchini, and P. M. Mannucci How I treat rare venous thromboses Blood, December 15, 2008; 112(13): 4818 - 4823. [Abstract] [Full Text] [PDF] F. Dentali, M. Gianni, M. A. Crowther, and W. Ageno Natural history of cerebral vein thrombosis: a systematic review Blood, August 15, 2006; 108(4): 1129 - 1134. [Abstract] [Full Text] [PDF]

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