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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1265-1275. Prepublished online as a Blood First Edition Paper on October 27, 2005; DOI 10.1182/blood-2005-09-3621. This Article Full Text (PDF) All Versions of this Article: 2005-09-3621v1 107/4/1265    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Olsen, A. L Articles by Weiss, M. J Search for Related Content PubMed PubMed Citation Articles by Olsen, A. L Articles by Weiss, M. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 9, 2005 Accepted October 9, 2005 Designer blood: creating hematopoietic lineages from embryonic stem cells Abby L Olsen, David L Stachura, and Mitchell J Weiss* Cell and Molecular Biology Graduate Program, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Combined Degree Graduate Program, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA Cell and Molecular Biology Graduate Program, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA The Children's Hospital of Philadelphia, Division of Hematology and the University of Pennsylvania, Philadelphia, PA, USA * Corresponding author; email: weissmi{at}email.chop.edu. Embryonic stem (ES) cells exhibit the remarkable capacity to become virtually any differentiated tissue upon appropriate manipulation in culture, a property that has been beneficial for studies of hematopoiesis. Until recently, the majority of this work utilized murine ES cells for basic research to elucidate fundamental properties of blood cell development and establish methods to derive specific mature lineages. Now, the advent of human ES cells sets the stage for more applied pursuits to generate transplantable cells for treating blood disorders. Current efforts are directed toward adapting in vitro hematopoietic differentiation methods developed for murine ES cells to human lines, identifying the key interspecies differences in biological properties of ES cells and overcoming current obstacles to generating ES cell-derived hematopoietic stem cells that are competent to repopulate adult hosts. The ultimate medical goal is to create patient-specific and generic ES cell lines that can be expanded in vitro, genetically altered and differentiated into cell types that can be used to treat hematopoietic diseases. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Zampetaki, L. Zeng, Q. Xiao, A. Margariti, Y. Hu, and Q. Xu Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-{alpha} is rescued by HDAC inhibitor trichostatin A Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1226 - C1238. [Abstract] [Full Text] [PDF]

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