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Blood, 15 April 2006, Vol. 107, No. 8, pp. 3034-3044. Prepublished online as a Blood First Edition Paper on January 5, 2006; DOI 10.1182/blood-2005-09-3679. This Article Full Text (PDF) All Versions of this Article: 2005-09-3679v1 107/8/3034    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Suarez, F. Articles by Lecuit, M. Search for Related Content PubMed PubMed Citation Articles by Suarez, F. Articles by Lecuit, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 15, 2005 Accepted December 5, 2005 Infection-associated lymphomas derived from marginal-zone B-cells: a model of antigen-driven lymphoproliferations Felipe Suarez, Olivier Lortholary, Olivier Hermine, and Marc Lecuit* Department of Hematology, Necker-Enfants Malades Hospital, Paris, France Department of Infectious Diseases, Necker-Enfants Malades Hospital, Paris, France; Molecular Mycology Unit, CNRS FRE 2849, Institut Pasteur, Paris, France Department of Hematology, Necker-Enfants Malades Hospital, Paris, France; CNRS UMR 8603, IFR94, Rene Descartes-Paris 5 University, Paris, France Department of Infectious Diseases, Necker-Enfants Malades Hospital, Paris, France; Bacteria-Cell Interactions Unit, INSERM U604, Institut Pasteur, Paris, France * Corresponding author; email: mlecuit{at}pasteur.fr. Non-Hodgkin lymphomas develop from nodal and extranodal lymphoid tissues. A distinct subset of extranodal lymphomas arising from B-cells of the marginal zone (MZ) of mucosa-associated lymphoid tissue (MALT) or spleen has been individualized. Growing evidence indicates that MZ lymphomas are associated with chronic antigenic stimulation by microbial pathogens and/or autoantigens. Molecular investigations have allowed the lengthening of the list of microbial species associated with MZ lymphoproliferations, which now comprises at least five distinct members: H. pylori, C. jejuni, B. burgdorferi, C. psittaci, and HCV. A pathophysiological scenario involving chronic and sustained stimulation of the immune system leading to lymphoid transformation has emerged. It defines a distinct category of infection-associated lymphoid malignancies, in which the infectious agent does not directly infect nor transform lymphoid cells, as do the lymphotropic oncogenic viruses EBV, HHV8 and HTLV1, but rather indirectly increases the probability of lymphoid transformation by chronically stimulating the immune system to maintain a protracted proliferative state. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Borie, M. Wislez, G. Thabut, M. Antoine, A. Rabbat, L-J. Couderc, I. Monnet, H. Nunes, F-X. Blanc, H. Mal, et al. Clinical characteristics and prognostic factors of pulmonary MALT lymphoma Eur. Respir. J., December 1, 2009; 34(6): 1408 - 1416. [Abstract] [Full Text] [PDF] G. Martinelli, G. Ryan, J. F. Seymour, L. Nassi, S. Steffanoni, A. Alietti, L. Calabrese, G. Pruneri, L. Santoro, M. Kuper-Hommel, et al. 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