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Blood, 15 May 2006, Vol. 107, No. 10, pp. 4189-4193. Prepublished online as a Blood First Edition Paper on January 19, 2006; DOI 10.1182/blood-2005-09-3741. This Article Full Text (PDF) All Versions of this Article: 2005-09-3741v1 107/10/4189    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Holler, E. Articles by Andreesen, R Search for Related Content PubMed PubMed Citation Articles by Holler, E. Articles by Andreesen, R Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 19, 2005 Accepted January 6, 2006 Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: Effect on long term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination Ernst Holler*, Gerhard Rogler, Julia Brenmoehl, Joachim Hahn, Hans Herfarth, Hildegard Greinix, A M Dickinson, G Socie, D Wolff, G Fischer, G Jackson, V Rocha, B Steiner, G Eissner, J Marienhagen, J Schoelmerich, and R Andreesen Department of Haematology/Oncology, University of Regensburg, Regensburg, Germany Department of Internal Medicine I, University of Regensburg, Regensburg, Germany Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria School of Laboratory and Clinical Sciences, University of Newcastle upon Tyne, Newcastle, United Kingdom HSCT Unit, Hopital St. Louis, Paris, France Department of Haematology and Oncology, University of Rostock, Rostock, Germany Department of Blood Group Serology, Medical University of Vienna, Vienna, Germany Centre for Clinical Trials, University of Regensburg, Regensburg, Germany * Corresponding author; email: ernst.holler{at}klinik.uni-regensburg.de. In order to assess the role of NOD2/CARD15 variants on the long term outcome of allogeneic stem cell transplantation in a genetically homogenous group, we extended our previous study (cohort I, n=78) and typed DNA from additional 225 recipients and their HLA-identical sibling donors (cohort II) from 4 European centres for NOD2/CARD15 SNPs. Results of genotyping were compared with clinical outcome: The strong association of NOD2/CARD15 variants with transplant related mortality (TRM) was confirmed in univariate and multivariate analysis: TRM increased from 20% in cohort I/ 22% in cohort II in recipient/donor pairs without any NOD2/CARD15 variants to 47% (cohort I)/ 32% (cohort II) in the presence of 1 variant in either donor or recipient and further to 57% (cohort I) / 74% (cohort II) in the presence of 2 or more variants (p 0.002 in both cohorts). NOD2/CARD15 SNPs were not associated with relapse rate but had a strong impact on overall survival. In an analysis of centre effects, the type of gastrointestinal decontamination was the only factor interfering with the prognostic significance of NOD2/CARD15 SNPs. Our data further support an interaction between gastrointestinal defense mechanisms, activation of the innate immune system and specific transplant related complications. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Socie and B. R. Blazar Acute graft-versus-host disease: from the bench to the bedside Blood, November 12, 2009; 114(20): 4327 - 4336. [Abstract] [Full Text] [PDF] J. L. Espinoza, A. Takami, M. Onizuka, H. Sao, H. Akiyama, K. Miyamura, S. Okamoto, M. Inoue, Y. Kanda, S. Ohtake, et al. NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies Haematologica, October 1, 2009; 94(10): 1427 - 1434. [Abstract] [Full Text] [PDF] O. Penack, O. M. Smith, A. Cunningham-Bussel, X. Liu, U. Rao, N. Yim, I.-K. Na, A. M. Holland, A. Ghosh, S. X. Lu, et al. NOD2 regulates hematopoietic cell function during graft-versus-host disease J. Exp. Med., September 28, 2009; 206(10): 2101 - 2110. [Abstract] [Full Text] [PDF] H. Hauser, O. Zach, O. Krieger, H. Kasparu, J. Koenig, M. Girschikofsky, R. Oberbauer, and D. Lutz A single nucleotide polymorphism at chromosome 2q21.3 (LCT -13910C>T) associates with clinical outcome after allogeneic hematopoietic stem cell transplantation Blood, September 1, 2008; 112(5): 2156 - 2159. [Abstract] [Full Text] [PDF] E. Holler, J. Hahn, R. Andreesen, G. Rogler, J. Brenmoehl, H. Greinix, A. M. Dickinson, G. Socie, D. Wolff, and J. Finke NOD2/CARD15 Polymorphisms in Allogeneic Stem-Cell Transplantation From Unrelated Donors: T Depletion Matters J. Clin. Oncol., January 10, 2008; 26(2): 338 - 339. [Full Text] [PDF] N. P. Mayor, B. E. Shaw, D. A. Hughes, H. 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