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Blood, 1 August 2006, Vol. 108, No. 3, pp. 983-985. Prepublished online as a Blood First Edition Paper on April 20, 2006; DOI 10.1182/blood-2005-09-3824. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2005-09-3824v1 108/3/983    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pesu, M. Articles by O'Shea, J. J Search for Related Content PubMed PubMed Citation Articles by Pesu, M. Articles by O'Shea, J. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 23, 2005 Accepted March 9, 2006 Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon- Marko Pesu*, Linda Muul, Yuka Kanno, and John J O'Shea Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA * Corresponding author; email: pesum{at}mail.nih.gov. Interleukin (IL) -12 is a major inducer of interferon gamma (IFN-) and the principal mediator of T helper (Th)1 differentiation. To identify IL-12-regulated genes, which might contribute to Th1 differentiation and IFNG regulation, we employed microarray analysis. Surprisingly, a ubiquitously expressed proprotein convertase (PC) furin, was one of the most consistently IL-12-induced genes in T cells and among PCs was the only one regulated by this cytokine. Furin was preferentially expressed in differentiated Th1 cells in a Stat4-dependent manner. Expression of furin enhanced IFN- secretion, whereas inhibition of furin interfered with IFN- production. Thus, we conclude that IL-12 induction of furin might represent a new aspect of IFN- regulation and control of Th1 differentiation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. R. Good, V. T. Thieu, A. N. Mathur, Q. Yu, G. L. Stritesky, N. Yeh, J. T. O'Malley, N. B. Perumal, and M. H. Kaplan Temporal Induction Pattern of STAT4 Target Genes Defines Potential for Th1 Lineage-Specific Programming J. Immunol., September 15, 2009; 183(6): 3839 - 3847. [Abstract] [Full Text] [PDF] W. T. Watford, B. D. Hissong, L. R. Durant, H. Yamane, L. M. Muul, Y. Kanno, C. M. Tato, H. L. Ramos, A. E. Berger, L. Mielke, et al. Tpl2 kinase regulates T cell interferon-{gamma} production and host resistance to Toxoplasma gondii J. Exp. Med., November 24, 2008; 205(12): 2803 - 2812. [Abstract] [Full Text] [PDF] M. J. Gros, P. Naquet, and R. R. Guinamard Cell Intrinsic TGF-{beta}1 Regulation of B Cells J. Immunol., June 15, 2008; 180(12): 8153 - 8158. [Abstract] [Full Text] [PDF] A. F. Arechiga, B. D. Bell, S. Leverrier, B. M. Weist, M. Porter, Z. Wu, Y. Kanno, S. J. Ramos, S. T. Ong, R. Siegel, et al. A Fas-Associated Death Domain Protein/Caspase-8-Signaling Axis Promotes S-Phase Entry and Maintains S6 Kinase Activity in T Cells Responding to IL-2 J. Immunol., October 15, 2007; 179(8): 5291 - 5300. [Abstract] [Full Text] [PDF]

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