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Blood, 1 June 2006, Vol. 107, No. 11, pp. 4475-4483. Prepublished online as a Blood First Edition Paper on February 7, 2006; DOI 10.1182/blood-2005-10-3994. This Article Full Text (PDF) All Versions of this Article: 2005-10-3994v1 107/11/4475    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Noble, A. Articles by Leggat, J. A Search for Related Content PubMed PubMed Citation Articles by Noble, A. Articles by Leggat, J. A Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 6, 2005 Accepted January 26, 2006 Cytokine-induced IL-10-secreting CD8 T cells represent a phenotypically distinct suppressor T cell lineage Alistair Noble*, Angela Giorgini, and Jamie A Leggat MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, United Kingdom * Corresponding author; email: alistair.noble{at}kcl.ac.uk. Regulatory T cell (Treg) populations control autoimmune and allergic immunopathology induced by self or foreign antigens. Several types of CD4+ MHC class II-restricted Treg have been characterized but the biology of CD8+, MHC class I-restricted Treg is less understood. We show here that CD8+ Treg are rapidly generated in the presence of IL-4 and IL-12, produce IL-10 and exhibit a unique cell surface phenotype with coexpression of activation and naive cell-associated markers. They block activation of naive or effector T cells and suppress IgG/IgE antibody responses and Graft-versus-Host disease in vivo. Suppression is dependent on cell contact and mediated by direct T cell:T cell interaction that antagonizes TCR signals. The data establish the existence of a CD8 T cell suppressor effector subset distinct in both phenotype and function from Tc1 and Tc2 cells. Production of such CD8 Treg has potential for cell-based therapy of CD4 or CD8 T cell-mediated disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: A tale of two T cells: suppressor CD8 T cells recalled to life Edmund K. Waller Blood 2006 107: 4203-4204. [Full Text] [PDF] This article has been cited by other articles: S. Kim, T. Shen, and B. Min Basophils Can Directly Present or Cross-Present Antigen to CD8 Lymphocytes and Alter CD8 T Cell Differentiation into IL-10-Producing Phenotypes J. Immunol., September 1, 2009; 183(5): 3033 - 3039. [Abstract] [Full Text] [PDF] R. Simone, A. Zicca, and D. Saverino The frequency of regulatory CD3+CD8+CD28-CD25+ T lymphocytes in human peripheral blood increases with age J. Leukoc. Biol., December 1, 2008; 84(6): 1454 - 1461. [Abstract] [Full Text] [PDF] M. Rifa'i, Z. Shi, S.-Y. Zhang, Y. H. Lee, H. Shiku, K.-i. Isobe, and H. Suzuki CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-{alpha}{beta}TCR interaction and become IL-10-producing active regulatory cells Int. Immunol., July 1, 2008; 20(7): 937 - 947. [Abstract] [Full Text] [PDF] Y. Fang, G. C. Sharp, and H. Braley-Mullen Interleukin-10 Promotes Resolution of Granulomatous Experimental Autoimmune Thyroiditis Am. J. Pathol., June 1, 2008; 172(6): 1591 - 1602. [Abstract] [Full Text] [PDF] A. Giorgini and A. Noble Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts J. Leukoc. Biol., November 1, 2007; 82(5): 1053 - 1061. [Abstract] [Full Text] [PDF] E. Billerbeck, H. E. Blum, and R. Thimme Parallel Expansion of Human Virus-Specific FoxP3- Effector Memory and De Novo-Generated FoxP3+ Regulatory CD8+ T Cells upon Antigen Recognition In Vitro J. Immunol., July 15, 2007; 179(2): 1039 - 1048. [Abstract] [Full Text] [PDF] C. F. Anderson, M. Oukka, V. J. Kuchroo, and D. Sacks CD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis J. Exp. Med., February 19, 2007; 204(2): 285 - 297. [Abstract] [Full Text] [PDF] M. d. l. L. Garcia-Hernandez, A. Gray, B. Hubby, and W. M. Kast In vivo Effects of Vaccination with Six-Transmembrane Epithelial Antigen of the Prostate: A Candidate Antigen for Treating Prostate Cancer Cancer Res., February 1, 2007; 67(3): 1344 - 1351. [Abstract] [Full Text] [PDF]

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