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Blood, 1 July 2006, Vol. 108, No. 1, pp. 379-381. Prepublished online as a Blood First Edition Paper on March 14, 2006; DOI 10.1182/blood-2005-10-4029. This Article Full Text (PDF) All Versions of this Article: 2005-10-4029v1 108/1/379    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Strouse, J. J Articles by Casella, J. F Search for Related Content PubMed PubMed Citation Articles by Strouse, J. J Articles by Casella, J. F Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 11, 2005 Accepted February 17, 2006 Inverse correlation between cerebral blood flow measured by continuous arterial spin-labeling (CASL) MRI and neurocognitive function in children with sickle cell anemia (SCA) John J Strouse*, Christiane S Cox, Elias R Melhem, Hanzhang Lu, Michael A Kraut, Alexander Razumovsky, Kaleb Yohay, Peter C van Zijl, and James F Casella Department of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Developmental and Cognitive Neurology, Kennedy-Krieger Institute, Baltimore, MD, USA Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA F. M. Kirby Research Center for Functional Imaging, Kennedy-Krieger Institute, Baltimore, MD, USA Neurocirculatory Physiology Laboratory, Departments of Neurology, Anesthesia, and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; F. M. Kirby Research Center for Functional Imaging, Kennedy-Krieger Institute, Baltimore, MD, USA * Corresponding author; email: jstrous1{at}jhmi.edu. Overt stroke, clinically "silent" cerebral infarct, and neurocognitive impairment are frequent complications of sickle cell anemia (SCA). Current imaging techniques have limited sensitivity and specificity to identify children at risk for neurocognitive impairment. We prospectively evaluated 24 children with SCA with a neurological exam, complete blood count, transcranial Doppler ultrasound, measurement of intelligence quotient (IQ), and magnetic resonance imaging (MRI) with measurement of cerebral blood flow (CBF) using continuous arterial spin-labeling (CASL) MRI. Average CBF to gray matter was 112 ± 36 ml/100g/min. We identified a strong inverse relationship between performance IQ and CBF (-1.5 points per 10 ml/100 g/min increase in CBF, p = 0.013). Elevated steady-state white blood cell count ( 14,000/ul) was associated with lower full scale IQ (86 ± 9 vs. 99 ± 10, p = 0.005). CASL MRI may identify children with neurocognitive impairment, before damage is evident by structural MRI or TCD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. W. van den Tweel, A. J. Nederveen, C. B. L. M. Majoie, J. H. van der Lee, L. Wagener-Schimmel, M. A. A. van Walderveen, B. T. P. The, P. J. Nederkoorn, H. Heijboer, and K. Fijnvandraat Cerebral Blood Flow Measurement in Children With Sickle Cell Disease Using Continuous Arterial Spin Labeling at 3.0-Tesla MRI Stroke, March 1, 2009; 40(3): 795 - 800. [Abstract] [Full Text] [PDF] Y.-S. Kim, E. Nur, E. J. van Beers, J. Truijen, S. C.A.T. Davis, B. J. Biemond, and J. J. van Lieshout Dynamic Cerebral Autoregulation in Homozygous Sickle Cell Disease Stroke, March 1, 2009; 40(3): 808 - 814. [Abstract] [Full Text] [PDF]

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