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Blood, 1 June 2006, Vol. 107, No. 11, pp. 4417-4423. Prepublished online as a Blood First Edition Paper on February 14, 2006; DOI 10.1182/blood-2005-10-4129. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-10-4129v1 107/11/4417    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mennechet, F. J Articles by Uze, G. Search for Related Content PubMed PubMed Citation Articles by Mennechet, F. J Articles by Uze, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 17, 2005 Accepted January 11, 2006 Interferon -treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells Franck J Mennechet and Gilles Uze* CNRS UMR 5124, University of Montpellier, Montpellier, France * Corresponding author; email: uze{at}univ-montp2.fr. The interferons (IFNs), also known as IL-28 and IL-29, are co-expressed with IFN following Toll Like Receptor (TLR) stimulation in human monocyte-derived dendritic cells (DCs). IFN shares with type I IFNs an intracellular signaling pathway which drives the expression of a common set of gene. However, IFN signaling is initiated through a membrane receptor system distinct from that of type I IFNs. Because IFNs produced by DCs in response to TLR stimulation are critical in both differentiation and maturation of DCs, we sought to investigate whether IFN exhibits specific effects on DCs differentiation. We show in this work that DCs acquire IFN responsiveness through the expression of the specific IFN receptor chain during their differentiation from monocytes. IFN-treated DCs express high levels of MHC I and II but low levels of costimulatory molecules. However, they express CCR7 and acquire the ability to migrate to lymph nodes when intravenously injected into SCID/Bg mice. In MLR cultures, IFN-treated DCs specifically induced an IL-2-dependent proliferation of a CD4+, CD25+, Foxp3+ T cell subset with contact-dependent suppressive activity on T cells proliferation initiated by fully mature DCs. IFN are thus able to generate tolerogenic DCs, an activity that could thwart IFN functions. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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