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Blood, 15 May 2006, Vol. 107, No. 10, pp. 4047-4052.
Prepublished online as a Blood First Edition Paper on January 19, 2006; DOI 10.1182/blood-2005-10-4213.
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Submitted October 24, 2005
Accepted January 2, 2006
Diffuse large B-cell lymphoma in pediatric patients predominantly belong to the germinal-center type B-cell lymphomas
Ilske Oschlies, Wolfram Klapper*, Martin Zimmermann, Matthias Krams, Hans-Heinrich Wacker, Birgit Burkhardt, Lana Harder, Reiner Siebert, Alfred Reiter, and Reza Parwaresch
Institute of Pathology, Department of Hematopathology and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
Department of Pediatric Hematology and Oncology, University of Hannover, Hannover, Germany; NHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig-University, Giessen, Germany
NHL-BFM Study Center, Department of Pediatric Hematology and Oncology, Justus-Liebig-University, Giessen, Germany
Institute of Human Genetics, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany
* Corresponding author; email: wklapper{at}path.uni-kiel.de.
Diffuse large B-cell lymphoma (DLBCL) in adults is a heterogeneous disease. Biological subgroups of DLBCL with a favorable prognosis (germinal center B-cell-like, GCB) and with a poor prognosis (activated B-cell-like, ABC) have been defined by gene expression profiling and can be distinguished by immunohistochemistry. In contrast to their adult counterpart, DLBCL in children have an excellent prognosis. We analyzed 63 cases of DLBCL in pediatric patients by immunohistochemistry and fluorescence in-situ hybridization (FISH) and found a striking predominance of a GCB subtype, which might explain the good clinical outcome in these lymphomas. Interestingly, fluorescence in-situ hybridization (FISH) applied to 50 of these cases as well as conventional cytogenetics available in three cases revealed absence of the translocation t(14;18) involving the BCL2 gene which is present in about 15% of adult GCB subtype DLBCL. Our data indicate that pediatric DLBCL differ from adult DLBCL and might comprise a biologically unique subgroup of DLBCL from which important insights into the pathogenesis and biology of this disease might be gained.
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