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Blood, 15 June 2006, Vol. 107, No. 12, pp. 4807-4816. Prepublished online as a Blood First Edition Paper on February 16, 2006; DOI 10.1182/blood-2005-11-4334. This Article Full Text (PDF) All Versions of this Article: 2005-11-4334v1 107/12/4807    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Starlets, D. Articles by Shachar, I. Search for Related Content PubMed PubMed Citation Articles by Starlets, D. Articles by Shachar, I. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 3, 2005 Accepted February 6, 2006 Cell surface CD74 initiates a signaling cascade leading to cell proliferation and survival Diana Starlets, Yael Gore, Inbal Binsky, Michal Haran, Nurit Harpaz, Lev Shvidel, Shirly Becker-Herman, Alain Berrebi, and Idit Shachar* Department of Immunology, Weizmann Institute of Science, Rehovot, Israel Hematology Institute, Kaplan Medical Center, Rehovot, Israel * Corresponding author; email: idit.shachar{at}weizmann.ac.il. CD74 is an integral membrane protein that was thought to function mainly as an MHC class II chaperone. However, recently CD74 was shown to have a role as an accessory signaling molecule. Our studies demonstrated that CD74 regulates B cell differentiation by inducing a pathway leading to the activation of transcription mediated by the NF-B p65/RelA homodimer and its coactivator, TAFII105. Here we show that CD74 stimulation with anti-CD74 antibody leads to an induction of a signaling cascade resulting in NF-B activation, entry of the stimulated cells into the S phase, elevation of DNA synthesis, cell division, and augmented expression of BCL-XL. These studies therefore demonstrate that surface CD74 functions as a survival receptor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. L. Martin-Ventura, J. Madrigal-Matute, B. Munoz-Garcia, L. M. Blanco-Colio, M. Van Oostrom, G. Zalba, A. Fortuno, C. Gomez-Guerrero, L. Ortega, A. Ortiz, et al. Increased CD74 expression in human atherosclerotic plaques: contribution to inflammatory responses in vascular cells Cardiovasc Res, August 1, 2009; 83(3): 586 - 594. [Abstract] [Full Text] [PDF] R. Leth-Larsen, R. Lund, H. V. Hansen, A.-V. Laenkholm, D. Tarin, O. N. Jensen, and H. J. 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