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Blood, 1 July 2006, Vol. 108, No. 1, pp. 63-73. Prepublished online as a Blood First Edition Paper on March 7, 2006; DOI 10.1182/blood-2005-11-4354. This Article Full Text (PDF) All Versions of this Article: 2005-11-4354v1 108/1/63    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Farag, S. S Articles by Bloomfield, C. D Search for Related Content PubMed PubMed Citation Articles by Farag, S. S Articles by Bloomfield, C. D Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 3, 2005 Accepted February 21, 2006 Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from cancer and leukemia group B 8461 Sherif S Farag*, Kellie J Archer, Krzysztof Mrozek, Amy S Ruppert, Andrew J Carroll, James W Vardiman, Mark J Pettenati, Maria R Baer, Mazin B Qumsiyeh, Prasad R Koduru, Yi Ning, Robert J Mayer, Richard M Stone, Richard A Larson, and Clara D Bloomfield The Ohio State University, Columbus, OH, USA Virginia Commonwealth University, Richmond, VA, USA; The CALGB Statistical Center, Durham, NC, USA The Ohio State University, Columbus, OH, USA; The CALGB Statistical Center, Durham, NC, USA University of Alabama at Birmingham, Birmingham, AL, USA University of Chicago, Chicago, IL, USA Wake Forest University, Winston-Salem, NC, USA Roswell Park Cancer Institute, Buffalo, NY, USA Duke University, Durham, NY, USA North Shore University, Manhasset, NY, USA University of Maryland, Baltimore, MD, USA Dana Farber Cancer Institute, Boston, MA, USA * Corresponding author; email: sherif.farag{at}osumc.edu. We investigated the relative prognostic significance of cytogenetics in 635 adult acute myeloid leukemia (AML) patients 60 years treated on front-line protocols. Classification trees and tree-structured survival analysis (TSSA) were used to identify important cytogenetic groups, and their prognostic significance was then assessed in multivariable analysis (MVA). Overall, 48.5% achieved complete remission (CR); 6.6% survived at 5 years. Complex karyotypes with 3 abnormalities (complex 3) and a group including "rare aberrations" predicted lower CR rates (25% and 30%) versus other patients (56%). Compared with complex 3, the odds of CR were significantly higher for non-complex karyotypes without "rare aberrations" on MVA. Cytogenetically, complex 5 predicted inferior disease-free survival on TSSA, remaining significant on MVA together with white cell count (WBC), gender, and age. For survival, complex 5, "rare aberrations", and core-binding factor (CBF) abnormalities were prognostic (P< 0.0001), with 5-year survivals of 0%, 0%, and 19.4%, respectively, and 7.5% for remaining patients. Together with WBC, marrow blasts, gender, and age, the cytogenetic groups remained significant on MVA. In conclusion, pretreatment cytogenetics adds to other prognostic factors in older AML patients. Patients with complex 5 appear to benefit minimally from current treatment and are better suited for investigational therapy or supportive care. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Prebet, N. Boissel, S. Reutenauer, X. Thomas, J. Delaunay, J.-Y. Cahn, A. Pigneux, B. Quesnel, F. Witz, S. Thepot, et al. Acute Myeloid Leukemia With Translocation (8;21) or Inversion (16) in Elderly Patients Treated With Conventional Chemotherapy: A Collaborative Study of the French CBF-AML Intergroup J. 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