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Blood, 15 July 2006, Vol. 108, No. 2, pp. 460-464. Prepublished online as a Blood First Edition Paper on March 21, 2006; DOI 10.1182/blood-2005-11-4407. This Article Full Text (PDF) All Versions of this Article: 2005-11-4407v1 108/2/460    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Arnold, D. M Articles by Walker, I. R Search for Related Content PubMed PubMed Citation Articles by Arnold, D. M Articles by Walker, I. R Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 8, 2005 Accepted March 7, 2006 Mortality rates and causes of death among all HIV-positive individuals with hemophilia in Canada over twenty-one years of follow up Donald M Arnold*, Jim A Julian, and Irwin R Walker Medicine, McMaster University, Hamilton, Ontario, Canada; Canadian Blood Services, Hamilton, Ontario, Canada Medicine, McMaster University, Hamilton, Ontario, Canada Medicine, McMaster University, Hamilton, Ontario, Canada; Association of Hemophilia Clinic Directors of Canada and Canadian Association of Nurses in Hemophilia Care, Toronto, Ontario, Canada; * Corresponding author; email: arnolddm{at}mcmaster.ca. Many individuals with hemophilia were infected with human immunodeficiency virus (HIV) in the early 1980s through contaminated blood products. Most were also co-infected with hepatitis C virus (HCV). Deaths among the entire cohort of HIV-positive hemophiliacs in Canada up to 2003 are described. Using registry data, we analyzed Kaplan-Meier survival curves, determined the effect of age at HIV seroconversion on mortality and described cause-specific proportional mortality patterns over time. Of 2,427 Canadians with hemophilia, 660 (27.2%) were HIV-positive, of whom 406 (61.5%) died. In contrast, 114 (6.5%) deaths occurred in HIV-negative controls. Median age at HIV seroconversion was 20 (range <1 to 67) and median survival was 15.0 years (95% confidence interval 13.6 to 16.4). Younger age at HIV seroconversion was associated with improved survival; however, this finding was not explained by differences in causes of death across age groups. Following the introduction of highly active antiretroviral therapy, the proportion of deaths due to acquired immune deficiency syndrome has decreased while the proportion of deaths due to liver disease has increased. There were 1,134 HCV-positive individuals, of whom only 444 (39.2%) were also HIV-positive. Liver disease is a growing health concern among many hemophiliacs, not only those who are HIV-positive. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Rotman and T. J. Liang Coinfection with Hepatitis C Virus and Human Immunodeficiency Virus: Virological, Immunological, and Clinical Outcomes J. Virol., August 1, 2009; 83(15): 7366 - 7374. [Full Text] [PDF]

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