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Blood, 15 May 2006, Vol. 107, No. 10, pp. 3925-3932. Prepublished online as a Blood First Edition Paper on January 17, 2006; DOI 10.1182/blood-2005-11-4502. This Article Full Text (PDF) All Versions of this Article: 2005-11-4502v1 107/10/3925    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Zhao, D.-M. Articles by Shevach, E. M Search for Related Content PubMed PubMed Citation Articles by Zhao, D.-M. Articles by Shevach, E. M Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 14, 2005 Accepted December 30, 2005 Activated CD4+CD25+ T cells selectively kill B lymphocytes Dong-Mei Zhao, Angela M Thornton, Richard J DiPaolo, and Ethan M Shevach* Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA * Corresponding author; email: eshevach{at}niaid.nih.gov. The suppressive capacity of naturally occurring mouse CD4+CD25+ T cells on T cell activation has been well documented. The present study is focused on the interaction of CD4+CD25+ T cells and B cells. By co-culturing pre-activated CD4+CD25+ T cells with B cells in the presence of polyclonal B cell activators, we found that B cell proliferation was significantly suppressed. The suppression of B cell proliferation was due to increased cell death caused by the CD4+CD25+ T cells in a cell-contact dependent manner. The induction of B cell death is not mediated by Fas-Fas ligand pathway, but surprisingly, depends on the up-regulation of perforin and granzymes in the CD4+CD25+ T cells. Furthermore, activated CD4+CD25+ T cells preferentially killed antigen presenting, but not bystander B cells. Our results demonstrate that CD4+CD25+ T cells can act directly on B cells and suggest that the prevention of autoimmunity by CD4+CD25+ T cells can be explained, at least in part, by the direct regulation of B cell function. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Tregs control B-cell life and death James J. Campbell Blood 2006 107: 3818-3819. [Full Text] [PDF] This article has been cited by other articles: R. Houot, M. J. Goldstein, H. E. Kohrt, J. H. Myklebust, A. A. Alizadeh, J. T. Lin, J. 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Tarleton Endogenous CD4+ CD25+ Regulatory T Cells Have a Limited Role in the Control of Trypanosoma cruzi Infection in Mice Infect. Immun., February 1, 2007; 75(2): 861 - 869. [Abstract] [Full Text] [PDF] N. Ralainirina, A. Poli, T. Michel, L. Poos, E. Andres, F. Hentges, and J. Zimmer Control of NK cell functions by CD4+CD25+ regulatory T cells J. Leukoc. Biol., January 1, 2007; 81(1): 144 - 153. [Abstract] [Full Text] [PDF] F. Venet, A. Pachot, A.-L. Debard, J. Bohe, J. Bienvenu, A. Lepape, W. S. Powell, and G. Monneret Human CD4+CD25+ Regulatory T Lymphocytes Inhibit Lipopolysaccharide-Induced Monocyte Survival through a Fas/Fas Ligand-Dependent Mechanism J. Immunol., November 1, 2006; 177(9): 6540 - 6547. [Abstract] [Full Text] [PDF] J. Carreras, A. Lopez-Guillermo, B. C. Fox, L. Colomo, A. Martinez, G. Roncador, E. Montserrat, E. Campo, and A. H. 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