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Blood, 1 August 2006, Vol. 108, No. 3, pp. 878-885. Prepublished online as a Blood First Edition Paper on February 28, 2006; DOI 10.1182/blood-2005-11-4545. This Article Full Text (PDF) All Versions of this Article: 2005-11-4545v1 108/3/878    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Harman, B. C Articles by Allman, D. Search for Related Content PubMed PubMed Citation Articles by Harman, B. C Articles by Allman, D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted November 16, 2005 Accepted February 9, 2006 Mouse plasmacytoid dendritic cells derive exclusively from estrogen-resistant myeloid progenitors Benjamin C Harman, Juli P Miller, Neda Nikbakht, Rachel Gerstein, and David Allman* Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA * Corresponding author; email: dallman{at}mail.med.upenn.edu. Current models predict that mouse plasmacytoid dendritic cells (PDCs) derive from lymphoid progenitors. However, we show PDCs arise exclusively from common myeloid progenitors (CMPs) characterized by low-level expression of several lymphoid-associated genes including a RAG2/GFP reporter transgene. This conclusion is supported by both adoptive transfer experiments and an estrogen treatment strategy that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP+ CMPs or the developmental kinetics, RAG-mediated recombinase activity, and cytokine production of PDCs. These data suggest that PDCs arise exclusively from early myeloid progenitors, and that promiscuous low-level expression of lymphoid-associated genes is a general feature of PDC progenitors among CMPs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. L. Esplin, R. S. Welner, Q. Zhang, L. A. Borghesi, and P. W. Kincade A differentiation pathway for B1 cells in adult bone marrow PNAS, April 7, 2009; 106(14): 5773 - 5778. [Abstract] [Full Text] [PDF] B. C. Harman, D. L. Northrup, and D. Allman Resolution of Unique Sca-1highc-Kit- Lymphoid-Biased Progenitors in Adult Bone Marrow J. Immunol., December 1, 2008; 181(11): 7514 - 7524. [Abstract] [Full Text] [PDF] H. Karsunky, M. A. Inlay, T. Serwold, D. Bhattacharya, and I. L. Weissman Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages Blood, June 15, 2008; 111(12): 5562 - 5570. [Abstract] [Full Text] [PDF] T. Marafioti, J. C. Paterson, E. Ballabio, K. K. Reichard, S. Tedoldi, K. Hollowood, M. Dictor, M.-L. Hansmann, S. A. Pileri, M. J. Dyer, et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells Blood, April 1, 2008; 111(7): 3778 - 3792. [Abstract] [Full Text] [PDF] K. Pilbeam, P. Basse, L. Brossay, N. Vujanovic, R. Gerstein, A. N. Vallejo, and L. Borghesi The Ontogeny and Fate of NK Cells Marked by Permanent DNA Rearrangements J. Immunol., February 1, 2008; 180(3): 1432 - 1441. [Abstract] [Full Text] [PDF] E. Carreras, S. Turner, V. Paharkova-Vatchkova, A. Mao, C. Dascher, and S. Kovats Estradiol Acts Directly on Bone Marrow Myeloid Progenitors to Differentially Regulate GM-CSF or Flt3 Ligand-Mediated Dendritic Cell Differentiation J. Immunol., January 15, 2008; 180(2): 727 - 738. [Abstract] [Full Text] [PDF] R. S. Welner, R. Pelayo, K. P. Garrett, X. Chen, S. S. Perry, X.-H. Sun, B. L. Kee, and P. W. Kincade Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors Blood, June 1, 2007; 109(11): 4825 - 4931. [Abstract] [Full Text] [PDF]

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