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Blood, 15 August 2006, Vol. 108, No. 4, pp. 1129-1134. Prepublished online as a Blood First Edition Paper on April 11, 2006; DOI 10.1182/blood-2005-12-4795. This Article Full Text (PDF) All Versions of this Article: 2005-12-4795v1 108/4/1129    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dentali, F. Articles by Ageno, W. Search for Related Content PubMed PubMed Citation Articles by Dentali, F. Articles by Ageno, W. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 13, 2005 Accepted March 23, 2006 Natural history of cerebral vein thrombosis: A systematic review Francesco Dentali, Monica Gianni, Mark A Crowther*, and Walter Ageno Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Clinical Medicine, University of Insubria, Varese, Italy Division of Cardiology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada; Department of Clinical Medicine, University of Insubria, Varese, Italy Department of Medicine, McMaster University, Hamilton, Ontario, Canada Department of Clinical Medicine, University of Insubria, Varese, Italy * Corresponding author; email: crowthrm{at}mcmaster.ca. Cerebral vein thrombosis (CVT) has been considered until a few years ago an uncommon disease with significant long-term morbidity and a high mortality rate. New non-invasive diagnostic techniques have increased the frequency with which this disease is diagnosed; despite this, there continues to be little data on its natural history. To evaluate the mortality rate, the rate of disability at long-term follow-up and the incidence of recurrences after a first episode of CVT; to determine clinical and radiological predictors of death and dependence; and to identify possible risk factors for recurrence. MEDLINE and EMBASE databases, reference lists of selected articles and authors' libraries Nineteen studies were identified. Mortality rate during peri-hospitalization period is 5.6 % (range 0 to 15.2%), and 9.4 % (range 0 to 39%) at the end of follow-up period. Eighty-eight percent of surviving patients recover completely or have only a mild functional or cognitive deficit. Two third of patients with CVT recanalized within the first few months after presentation and 2.8 % (range 0 to 11.7%) had objectively confirmed recurrence. We conclude that patients with CVT have a low risk of death and most patients have a good long-term prognosis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. M. Ferro, P. Canhao, M.-G. Bousser, J. Stam, F. Barinagarrementeria, and for the ISCVT Investigators Early Seizures in Cerebral Vein and Dural Sinus Thrombosis: Risk Factors and Role of Antiepileptics Stroke, April 1, 2008; 39(4): 1152 - 1158. [Abstract] [Full Text] [PDF] T. Barbui and G. Finazzi Myeloproliferative Disease in Pregnancy and Other Management Issues Hematology, January 1, 2006; 2006(1): 246 - 252. [Abstract] [Full Text] [PDF]

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