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Blood, 15 July 2006, Vol. 108, No. 2, pp. 600-608. Prepublished online as a Blood First Edition Paper on March 28, 2006April 4, 2006; DOI 10.1182/blood-2005-12-4827. This Article Full Text (PDF) All Versions of this Article: 2005-12-4827v1 2005-12-4827v2 108/2/600    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cornish, G. H Articles by Cantrell, D. A Search for Related Content PubMed PubMed Citation Articles by Cornish, G. H Articles by Cantrell, D. A Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 6, 2005 Accepted March 10, 2006 Differential regulation of T cell growth by Interleukin 2 and IL-15 Georgina H Cornish, Linda V Sinclair, and Doreen A Cantrell* Cancer Research UK, London, England, United Kingdom; The Edward Jenner Institute for Vaccine Research, Berkshire, England, United Kingdom; School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom * Corresponding author; email: d.a.cantrell{at}dundee.ac.uk. Interleukin 2 (IL-2) and IL-15 signal via the common gamma chain (c) and IL-2 receptor chain (CD122) subunits but direct distinct physiological and immunotherapeutic responses in T cells. The present study provides some insights about why IL-2 and IL-15 differentially regulate T cell function by revealing that these cytokines are strikingly distinct in their ability to control protein synthesis and T cell mass. IL-2 and IL-15 are shown to be equivalent mitogens for antigen stimulated CD8+ T cells but not equivalent growth factors. Antigen primed T cells cannot autonomously maintain amino acid incorporation or de novo protein synthesis without exogenous cytokine stimulation. Both IL-2 and IL-15 induce amino acid uptake and protein synthesis in antigen activated T cells however, the IL-2 response is strikingly more potent than the IL-15 response. The differential action of IL-2 and IL-15 on amino acid uptake and protein synthesis is explained by temporal differences in signalling induced by these two cytokines. Hence the present results show that cytokines that are equivalent mitogens can have different potency in terms of regulating protein synthesis and cell growth. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Time to restore individual rights for IL-2 and IL-15? Yutaka Tagaya Blood 2006 108: 409-410. [Full Text] [PDF] This article has been cited by other articles: M. Terabe, Y. Tagaya, Q. Zhu, L. Granger, M. Roederer, T. A. Waldmann, and J. A. Berzofsky IL-15 Expands Unconventional CD8{alpha}{alpha}NK1.1+ T Cells but Not V{alpha}14J{alpha}18+ NKT Cells J. Immunol., June 1, 2008; 180(11): 7276 - 7286. [Abstract] [Full Text] [PDF] M. J. Lindemann, Z. Hu, M. Benczik, K. D. Liu, and S. L. Gaffen Differential Regulation of the IL-17 Receptor by {gamma}c Cytokines: INHIBITORY SIGNALING BY THE PHOSPHATIDYLINOSITOL 3-KINASE PATHWAY J. Biol. Chem., May 16, 2008; 283(20): 14100 - 14108. [Abstract] [Full Text] [PDF] M. Marzec, K. Halasa, M. Kasprzycka, M. Wysocka, X. Liu, J. W. Tobias, D. Baldwin, Q. Zhang, N. Odum, A. H. Rook, et al. 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[Abstract] [Full Text] [PDF] C. Eidenschenk, E. Jouanguy, A. Alcais, J.-J. Mention, B. Pasquier, I. M. Fleckenstein, A. Puel, L. Gineau, J.-C. Carel, E. Vivier, et al. Familial NK Cell Deficiency Associated with Impaired IL-2- and IL-15-Dependent Survival of Lymphocytes J. Immunol., December 15, 2006; 177(12): 8835 - 8843. [Abstract] [Full Text] [PDF] P. Tamas, S. A. Hawley, R. G. Clarke, K. J. Mustard, K. Green, D. G. Hardie, and D. A. Cantrell Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes J. Exp. Med., July 10, 2006; 203(7): 1665 - 1670. [Abstract] [Full Text] [PDF]

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