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 Blood, 15 July 2006, Vol. 108, No. 2, pp. 745-748.
Prepublished online as a Blood First Edition Paper on March 28, 2006; DOI 10.1182/blood-2005-12-5156.

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Submitted December 29, 2005
Accepted February 27, 2006

The neuropathological phenotype of experimental ovine BSE is maintained after blood transfusion

Silvia Siso*, Lorenzo Gonzalez, Fiona Houston, Nora Hunter, Stuart Martin, and Martin Jeffrey

Veterinary Laboratories Agency (VLA-Lasswade), Midlothian, Scotland, United Kingdom
Institute for Animal Health, Berkshire, England, United Kingdom
Institute for Animal Health Neuropathogenesis Unit, Edinburgh, Scotland, United Kingdom

* Corresponding author; email: s.siso{at}vla.defra.gsi.gov.uk.

Iatrogenic transmission by blood transfusion has been described in cases of human vCJD, experimental ovine BSE and natural sheep scrapie, demonstrating that blood in these prion diseases is infectious. However, the possible effect of the transfusion, derived from differences in the inoculum (blood) and the route of infection (intravenous), on the pathological phenotype of the disease in the recipients is not known. This study describes the neuropathological phenotype of PrPd accumulation in sheep succumbing to neurological disease after blood transfusion from donors experimentally infected with BSE; these were either clinically or subclinically affected at the time of donation. We demonstrate that blood can become infectious at early stages of ovine BSE infection and that the PrPd immunohistochemical phenotype is maintained after transfusion. This suggests that a change in the pathological phenotype of vCJD would not be expected as a result of exposure to infected blood.


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