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Blood, 1 July 2006, Vol. 108, No. 1, pp. 103-106. Prepublished online as a Blood First Edition Paper on March 2, 2006; DOI 10.1182/blood-2006-01-0054. This Article Full Text (PDF) All Versions of this Article: 2006-01-0054v1 108/1/103    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Siu, C.-W. Articles by Tse, H.-F. Search for Related Content PubMed PubMed Citation Articles by Siu, C.-W. Articles by Tse, H.-F. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 12, 2006 Accepted February 21, 2006 Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications on long-term cardiac safety Chung-Wah Siu, Wing-Yan Au, Cindy Yung, Cyrus R Kumana, Chu-Pak Lau, Yok-Lam Kwong*, and Hung-Fat Tse Divisions of Cardiology, Hematology, and Clinical Pharmacology, Department of Medicine, University of Hong Kong, Hong Kong, China * Corresponding author; email: ylkwong{at}hkucc.hku.hk. Ventricular tachyarrhythmias may occur during intravenous (i.v.) arsenic trioxide (As2O3). This has not happened during oral-As2O3. Sixteen patients were studied by electrocardiography and 24-hour Holter monitoring at baseline, during and after oral-As2O3 (As2O3-ON, As2O3-OFF). QT and QTc were significantly longer during As2O3-ON than As2O3-OFF, but QT and QTc dispersions were comparable. 24-hour heart rates were higher during As2O3-ON than As2O3-OFF. QTc-intervals at each hour were longer during As2O3-ON than As2O3-OFF. However, QTc prolongation > 30 milliseconds only occurred at one time-point (2 hours) after oral-As2O3, resulting in QTc > 500 milliseconds in 3/16 patients, all within 4 hours of oral-As2O3. Although the standard deviation of normal RR-interval was lower during As2O3-ON, ratios of low frequency to high frequency power for As2O3-ON and As2O3-OFF were comparable. No ventricular proarrhythmias were observed. These observations, due to the lower peak plasma arsenic reached during oral-As2O3, may explain the relative cardiac safety of oral-As2O3. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: W.-Y. Au, S. Tam, B. M. Fong, and Y.-L. Kwong Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy Blood, November 1, 2008; 112(9): 3587 - 3590. [Abstract] [Full Text] [PDF] P. Bobe, D. Bonardelle, K. Benihoud, P. Opolon, and M. K. Chelbi-Alix Arsenic trioxide: a promising novel therapeutic agent for lymphoproliferative and autoimmune syndromes in MRL/lpr mice Blood, December 15, 2006; 108(13): 3967 - 3975. [Abstract] [Full Text] [PDF]

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