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Blood, 1 August 2006, Vol. 108, No. 3, pp. 1100-1105.
Prepublished online as a Blood First Edition Paper on March 16, 2006; DOI 10.1182/blood-2006-01-0176.
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Submitted January 17, 2006
Accepted March 4, 2006
Spermatogenesis in long-term survivors after allogeneic hematopoietic stem cells transplantation is associated with age, time interval since transplantation and apparently with absence of chronic GvHD
Alicia Rovo*, Andre Tichelli, Jakob R Passweg, Dominik Heim, Sandrine Meyer-Monard, Wolfgang Holzgreve, Alois Gratwohl, and Christian De Geyter
Hematology Department, University Hospital Basel, Basel, Switzerland
University Women's Hospital, University Hospital Basel, Basel, Switzerland
* Corresponding author; email: RovoA{at}uhbs.ch.
To asses factors associated with spermatogenesis after allogeneic hematopoietic stem cell transplantation (HSCT). In a prospective, single center cross-sectional study, all consecutive males  18 years old and in complete remission 2 years after HSCT were invited to participate. Seminal fluid analysis was performed on freshly collected samples according to WHO guidelines. Between April 2003 and June 2004, 39 patients were included The median age at semen analysis was 34 years (range 20-59), and the median time interval between HSCT and sperm analysis 9 years (range 2-20). Thirty two patients (82%) received TBI (10Gy) as part of their conditioning regimen. Eleven out of 39 (28%) patients showed some spermatogenesis. Patients with detectable spermatozoa in the ejaculate were younger at HSCT (median age 19 versus 28 years; p=0.004), had a longer interval since HSCT (median time 12 versus 7 years; p=0.019) and were more often without chronic GvHD (2 of 11 patients versus 16 of 28; p=0.03). Nine of 16 patients (56%) transplanted at age below 25 years showed some degree of spermatogenesis. In conclusions, Long-term survivors, younger than 25 years at HSCT and apparently in absence of chronic GvHD have a reasonable likelihood of spermatogenesis even when conditioned with standard dose TBI.
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