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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by ENG, L.-I. L. Articles by THURAISINGHAM, V. Search for Related Content PubMed PubMed Citation Articles by ENG, L.-I. L. Articles by THURAISINGHAM, V. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1966, Vol. 28, No. 6, pp. 830-839. © 1966 American Society of Hematology, Inc. Further Cases of Hb Q-H Disease (Hb Q- Thalassemia) LIE-INJO LUAN ENG 1, R. P. PILLAY 1, and V. THURAISINGHAM 1 1 G. W. Hooper Foundation and the Hematology Unit, Department of Medicine, University of California Medical Center, San Francisco, Calif.; the General Hospital, Kuala Lumpur, Malaysia; and the General Hospital, Penang, Malaysia. Case reports of four patients, all Chinese, with Hb Q-H disease—also called Hb Q- thalassemia—are presented. Three were siblings. Symptoms of chronic hemolytic anemia with jaundice and hepatosplenomegaly were present in all four subjects. The red blood cells were microcytic. Slight hypochromia was present in three of the cases. Poikilo- and anisocytosis with target cells and small intraerythrocytic crystals were found in the blood. Starch-gel electrophoresis revealed the presence of a large amount of Hb Q, a small amount of Hb H, and a minor slow-moving hemoglobin component with a mobility as much behind Hb A2 as Hb Q was behind Hb A. A small amount of Hb "Bart’s" was probably also present. The minor slow-moving component was thought to represent Hb 2Q2A2 or Hb Q2. Hb A and Hb A2 were not seen except after recent blood transfusion. Study of hemoglobin polypeptide chains showed the presence of normal A-chains and abnormal Q-chains, without demonstrable A-chains in the first three patients. In Patient #4 normal A-chains were demonstrable only after recent blood transfusion. The mother of the three siblings was heterozygous for Hb A; the father had -thalassemia trait. Submitted on September 7, 1965 Accepted on April 23, 1966 CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K F S Leung, E S K Ma, A Y Y Chan, and L C Chan Clinical phenotype of haemoglobin Q-H disease J. Clin. Pathol., January 1, 2004; 57(1): 81 - 82. [Abstract] [Full Text] [PDF]

	Copyright © 1966 by American Society of Hematology         Online ISSN: 1528-0020