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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by KATTLOVE, H. E. Articles by SPAET, T. H. Search for Related Content PubMed PubMed Citation Articles by KATTLOVE, H. E. Articles by SPAET, T. H. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1970, Vol. 35, No. 5, pp. 659-668. © 1970 American Society of Hematology, Inc. The Effect of Chromium on Platelet Function In Vitro HERMAN E. KATTLOVE 1 and THEODORE H. SPAET 1 1 Montefiore Hospital and Medical Center, Bronx, N. Y. Sodium chromate inhibits platelet function in vitro. The primary effect is inhibition of connective tissue-induced aggregation. In addition, the primary wave of epinephrine-induced aggregation is moderately inhibited and adenosine diphosphate-induced aggregation is mildly inhibited. The effect on connective tissue-induced aggregation is due to inhibition of the platelet "release reaction"; chromate inhibited the release of adenine nucleotides, 14C labeled serotonin and the activation of platelet factor III normally caused by connective tissue. The amount of chromium which must be bound to platelets to inhibit aggregation is 10-100 times the amount of radioactive chromium bound to platelets under the usual conditions of labeling for survival studies. However, this does not imply that chromium labeled platelets function normally. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1970 by American Society of Hematology         Online ISSN: 1528-0020