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Protein-mediated uptake of vitamin B12 by isolated mitochondria

RA Gams, EM Ryel and F Ostroy

Protein-mediated B12 uptake by isolated rat liver mitochondria has been shown to be enhanced by plasma transcobalamin (TC-II) but not by salivary R binder in vitro. The process is enhanced by calcium and depends on active mitochondrial respiration. Following uptake, cyanocobalamin is converted to adenosyl and methylcobalamins and released from the mitochondria. TC-II appears to be required for both cellular and mitochondrial uptake of vitamin B12.

Volume 47, Issue 6, pp. 923-930, 06/01/1976
Copyright © 1976 by The American Society of Hematology


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  Copyright © 1976 by American Society of Hematology         Online ISSN: 1528-0020