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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Buchanan, G. R. Articles by Handin, R. I. Search for Related Content PubMed PubMed Citation Articles by Buchanan, G. R. Articles by Handin, R. I. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Platelet function in the Chediak-Higashi syndrome GR Buchanan and RI Handin Platelet function studies were performed on two patients with the Chediak-Higashi syndrome, one of whom had a history of easy bruising unrelated to thrombocytopenia. Both patients had prolonged bleeding times, abnormal platelet aggregation, and a defect of platelet storage granules, manifested by reduced platelet ADP, an increased ATP/ADP ratio, increased adenine nucleotide specific radioactivity after 3H- adenine labeling, and decreased platelet uptake of radioactive 5- hydroxytryptamine. These findings confirm preliminary data in animals with the Chediak-Higashi syndrome, provide and explanation for impaired primary hemostasis in these patients, and illustrate another disorder in which platelet storage-pool deficiency occurs. Volume 47, Issue 6, pp. 941-948, 06/01/1976 Copyright © 1976 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. J. SHATTIL and J. S. BENNETT Platelets and Their Membranes in Hemostasis: Physiology and Pathophysiology Ann Intern Med, January 1, 1981; 94(1): 108 - 118. [Abstract] [PDF]

	Copyright © 1976 by American Society of Hematology         Online ISSN: 1528-0020