SEARCH:   Advanced

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brown, C. 3. Articles by Williams, T. J. Search for Related Content PubMed PubMed Citation Articles by Brown, C. 3. Articles by Williams, T. J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Defective platelet function following the administration of penicillin compounds CH Brown , MJ Bradshaw, EA Natelson, CP Alfrey and TW Williams Platelet function and blood coagulation were studied in five human volunteers receiving penicillin-G in incremental doses of 1.2--48 million U/day, in six volunteers receiving ampicillin in incremental doses of 60--300 mg/kg/day (4--20 g/day), and in six volunteers receiving methicillin in incremental doses of 60--300 mg/kg/day. Coagulation tests remained normal in all 17 volunteers. However, ADP- induced platelet aggregation became abnormal in every subject except one receiving ampicillin and one receiving methicillin. Defective aggregation occurred with predictability with the following doses: penicillin-G, 24 million U/day; ampicillin, 300 mg/kg/day; methicillin, 300 mg/kg/day. All volunteers given penicillin-G and all given ampicillin experienced dose-related prolongation of bleeding time which did not occur with methicillin. Striking prolongation of bleeding time occurred only with penicillin-G in doses of 48 million U/day. Other tests of platelet function including clot retraction, platelet factor 3 availability, and collagen-induced or epinephrine-induced aggregation remained normal during the administration of these drugs. Measurement of intracellular adenine nucleotides revealed that the ADP and ATP content of platelets was unaffected. It appears that at least one mechanism by which the penicillin compounds alter platelet behavior is by interfering with activation of these cells by ADP. Volume 47, Issue 6, pp. 949-956, 06/01/1976 Copyright © 1976 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. R. Weitekamp and R. C. Aber Prolonged Bleeding Times and Bleeding Diathesis Associated With Moxalactam Administration JAMA, January 7, 1983; 249(1): 69 - 71. [Abstract] [PDF]

	Copyright © 1976 by American Society of Hematology         Online ISSN: 1528-0020