Duplication of part of the long arm of chromosome 1 in marrow cells of a
treated case of myelomatosis
AI Spriggs, JM Holt and J Bedford
In a case of classical myelomatosis treated with melphalan, a clone of
cells with a chromosomal abnormality was found in the bone marrow during
remission. There was good reason to think that the hemopoietic cells,
rather than plasmacytoma cells, were implicated. Although the clone
persisted, no evidence of leukemia developed over a period of observation
of 2 yr. The anomaly was interpreted as a duplication of part of the long
arm of chromosome 1, which appeared to involve the segment q21 to q31.
Volume 48,
Issue 4,
pp. 595-599,
10/01/1976
Copyright © 1976 by The American Society of Hematology
