Chromosomes and causation of human cancer and leukemia. XXI.
Cytogenetically unusual cases of leukemia
S Sonta, M Oshimura and AA Sandberg
Three male patients with leukemia were found with banding techniques to
have unusual cytogenetic pictures in the cells of their marrow, spleen or
blood. Case No. 1 (78 yr old) was that of a Ph1-negative CML with a missing
Y in the blood (cultured without PHA) and marrow cells. The patient is
still alive and responding to therapy. Case No 2 (54 yr old) was considered
prior to admission to have either CML or AML, but was shown, in fact, to be
in the blastic phase of CML; all the cells in his marrow and spleen were
Ph1-positive, but with no evidence of a translocation. Other karyotypic
findings (+8, +11, +13, +21) frequently encountered in the blastic phase of
CML were present in the cells of this patient. Case No. 3 (50 yr old) with
AML was shown to have a Ph1 resulting from a standard translocation, i.e.,
[t(9;22) (q34;q11)], in a substantial number of the cells in the marrrow
and blood (cultured without PHA). The implications of these unusual
findings are discussed in relation to the chromosomal pictures usually
encountered in these states.
Volume 48,
Issue 5,
pp. 697-705,
11/01/1976
Copyright © 1976 by The American Society of Hematology
