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Demonstration of granulocytic proteases in plasma of patients with acute
leukemia and septicemia with coagulation defects
R Egbring, W Schmidt, G Fuchs and K Havemann
To show whether direct proteolysis of coagulation factors may play a role
in patients with so-called consumption coagulopathy, granulocytic neutral
proteases in the plasma of patients with acute myelocytic leukemia and
septicemia were assayed by one- and two-dimensional Laurell
electrophoresis. Complexes between serum alpha1-antitrypsin and
elastase-like granulocytic protease could be demonstrated in those patients
with acute myelocytic leukemia and septicemia who also had moderate or
severe coagulation defects. Despite the presence of a high antiprotease
potential, addition of the elastase-like enzyme to normal plasma resulted
in coagulation defects in vitro comparable to those seen in the patients.
These results and the ability of the elastase- like protease to destroy
isolated clotting factors suggested that in certain types of coagulation
factor deficiencies direct proteolysis rather than consumption of clotting
factors due to disseminated intravascular coagulation may be operational.
Volume 49,
Issue 2,
pp. 219-231,
02/01/1977
Copyright © 1977 by The American Society of Hematology
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