Techniques for demonstration of the specificity of circulating
anticoagulants against antihemophilic factor (factor VIII), with studies of
two cases possibly related to diphenylhydantoin therapy
MC Poon, H Saito, OD Ratnoff, WB Forman and J Wisnieski
Circulating anticoagulants against antihemophilic factor (AHF, factor VIII)
sometimes seem to inactivate other clotting factors as well. Measurements
of the concentration of clotting factors in highly diluted plasma, or after
neutralization of the anticoagulant with purified AHF, have demonstrated
the specific nature of the anticoagulant in a patient under treatment with
diphenylhydantoin. A second case in a patient treated with this agent, and
with penicillin, an agent previously associated with the evolution of
circulating anticoagulants, is also described.
Volume 49,
Issue 3,
pp. 477-482,
03/01/1977
Copyright © 1977 by The American Society of Hematology
