Effects of partial hepatectomy on extrarenal erythropoietin production in
rats
A Anagnostou, S Schade, J Barone and W Fried
Studies were performed to determine the effects of partial hepatectomy on
extra-renal erythropoietin production. Rats were either partially
hepatectomized or sham operated. At intervals of from 5 min to 7 days
afterward, both kidneys were removed from cohorts of the above two groups
of rats and the animals were then exposed to hypoxia for 7.5 hr.
Immediately afterward, their plasma was collected and its erythropoietin
titer was assayed. Rats which were partially hepatectomized 2-4 days prior
to nephrectomy and hypoxia had significantly higher plasma erythropoietin
levels than did sham- operated controls, whereas rats hepatectomized 5 min,
1 day, or 7 days prior to nephrectomy and hypoxia did not. These data are
consistent with the conclusion that extrarenal erythropoietin production is
enhanced in association with rapid regeneration of hepatic cells.
Volume 50,
Issue 3,
pp. 457-462,
09/01/1977
Copyright © 1977 by The American Society of Hematology
