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Intermittent combination chemotherapy with adriamycin for childhood acute
lymphoblastic leukemia: clinical results
SE Sallan, BM Cammita, JR Cassady, DG Nathan and E Frei
One hundred thirty-seven children with previously untreated acute
lymphoblastic leukemia were entered into a new program that included
intermittent combination chemotherapy featuring Adriamycin. Remission
induction was initially randomized to vincristine and prednisone with or
without an anthracycline. All children received asparaginase consolidation
and central nervous system prophylaxis with cranial irradiation and
intrathecal methotrexate. There were no primary failures of CNS
prophylaxis. Complications were primarily infectious. Clinical evidence of
cardiotoxicity and leukoencephalopathy were not observed. The time to enter
complete remission and the presence of an anterior mediastinal mass at
diagnosis were found to be statistically significant adverse prognostic
factors, whereas presenting age and white blood count were not. With a
median follow-up of 26 mo, and using life plot analysis, 65% of the
children have remianed in continuous complete remission.
Volume 51,
Issue 3,
pp. 425-433,
03/01/1978
Copyright © 1978 by The American Society of Hematology
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