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B Morse, D Giuliani, T Fredrickson and J LoBue
A variant of Rauscher leukemia virus, designated RLV-A, induced a slow
progressive impairment of erythropoiesis in BALB/c mice. Identified in this
study were a shortened red cell 51-cr half-time, anemia with indices
showing minimal but significant hypochromia, ineffective erythropoiesis,
and infiltration of the liver, spleen, and peripheral blood with erythroid
pecursors. Ferrokinetic studies indicated a normal plasma iron turnover in
infected mice but a decreased red cell iron turnover. Large amounts of 59Fe
were taken up by the enlarged liver and spleen. Peak splenic heme 59Fe
synthesis was delayed 12 hr in the infected mice. The substantial increase
in the splenic intraerythrocytic nonheme iron pool and the hypochromic
indices indicate a process analogous to that seen in the sideroblastic
anemias. The disease produced by this RLV-A variant may prove useful for
studying various aspects of the preleukemic sideroblastic anemias and
DiGuglielmo syndrome.
This article has been cited by other articles:
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| Copyright © 1978 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
