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GC Bagby , K Richert-Boe and RD Koler
In 1954 a then 31-yr-old male was found to have erythrocytosis. Over the
ensuing decade he received 72 mCi32P. In 1964 his daughters were found to
have erythrocytosis. Further investigation led to the discovery of
hemoglobin Yakima, a variant with high oxygen affinity. He received no
further therapy and was well until 1975, when he developed the preleukemic
syndrome. Within 12 mo. he developed acute nonlymphocytic leukemia
accompanied by fetal erythropoiesis. Because the inital discovery of this
type of hemoglobinopathy came 27 yr after the introduction of 32P for use
in the treatment of polycythemia vera, and because there are now known to
be more than 39 different high- oxygen-affinity hemoglobins, we anticipate
that more patients such as ours have been exposed to 32P. The exposed
population should be cosely followed, since this will likely permit
assessment of the risk of 32P- induced leukemia in a nonneoplastic
condition.
This article has been cited by other articles:
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| Copyright © 1978 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
