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Genetic control of F cells in human adults
MA Zago, WG Wood, JB Clegg, DJ Weatherall, M O'Sullivan and H Gunson
Hb F levels were determined on samples from 750 normal blood donors. Six
individuals (0.8%) had Hb F levels in excess of 1.1%, the upper end of the
continuous distribution. Eight individuals at the upper end and 7
individuals at the lower end of the range were selected for family studies.
These studies revealed that the control of Hb F levels in adults, as judged
by the more sensitive F-cell technique, has a major genetic component.
Structural analysis of the Hb F in several cases demonstrated that both G
gamma and A gamma chains were present, but in variable proportions. These
results are discussed in light of current concepts of adult F-cell
production.
Volume 53,
Issue 5,
pp. 977-986,
05/01/1979
Copyright © 1979 by The American Society of Hematology
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