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A mechanism for the hydroperoxide-mediated inactivation of prostacyclin
synthetase
SJ Weiss, J Turk and P Needleman
Hydroxyl radical generation was demonstrated during heme-catalyzed
decomposition of 15-hydroperoxy arachidonic acid. The hydroperoxide-
mediated inactivation of prostacyclin synthetase seems to be related to the
generation of this highly reactive species. A relationship between
hydroperoxides and the hydroxyl radical may be important in the modulation
of prostacyclin synthesis in diseased states.
Volume 53,
Issue 6,
pp. 1191-1196,
06/01/1979
Copyright © 1979 by The American Society of Hematology
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