Lipopolysaccharide responsiveness of malignant lymphoid cells in a patient
with hairy cell leukemia
E Tatsumi, N Domae, Y Takiuchi, H Sawada, S Shirakawa and H Uchino
The malignant cells in a patient with hairy cell leukemia responded most
evidently to lipopolysaccharide (LPS) in in vitro culture for 3 1/2 days
when the conventional tritiated thymidine uptake method was used. Since the
malignant cells from patients with several other forms of leukemia and the
peripheral blood mononuclear cells from healthy individuals did not show a
comparable degree of responsiveness to LPS, we could exclude the
possibility that this response was due to effects on contaminating normal
mononuclear cells or to the nonspecific conditioning effect through
LPS-affected contaminating normal monocytes. Morphological changes were
observed with photo- and electronmicroscopy. It is likely that the hairy
cells from the patient did respond to LPS, and whether or not this
phenomenon may be confined to this type of lymphoid leukemia is not being
investigated.
Volume 54,
Issue 2,
pp. 524-529,
08/01/1979
Copyright © 1979 by The American Society of Hematology
