Studies in acute leukemia. I. Antibody-dependent and spontaneous cellular
cytotoxicity by leukemic blasts from patients with acute nonlymphoid
leukemia
G Fernandes, T Garrett, M Nair, D Straus, RA Good and S Gupta
Leukemic blasts from patients with acute nonlymphoid leukemia were examined
for the presence of Ig, receptors for IgGFc, and for their capacity to
mediate antibody-dependent cellular cytotoxicity (ADCC) against chicken red
blood cells (RBC) coated with IgG and spontaneous cell-mediated
cytotoxicity (SCMC) against cells of K562 cell line. Leukemic blasts from
acute myeloblastic leukemia (AML) patients lacked both Fc receptors and Ig
on their surface, had no SCMC activity and majority, but not all of them,
lacked ADCC activity. Leukemic blasts from patients with acute monocytic
leukemia (AMOL) had Fc receptors, and 50% had IgG on their surface. IgG was
cytophilic and appeared not to be directed against cell-surface antigens.
This antibody did not interfere with the ADCC activity of leukemic cells.
Leukemic blasts from majority of patients with AMOL mediated ADCC, but had
no SCMC activity. An association between ADCC and presence of Fc receptor
was observed.
Volume 54,
Issue 3,
pp. 573-580,
09/01/1979
Copyright © 1979 by The American Society of Hematology
