Fetal erythropoiesis and hemoglobin ontogeny in tail-short (Ts/+) mutant
mice
TW Brotherton, DH Chui, EC McFarland and ES Russell
Mutant Ts/+ fetuses are developmentally retarded as compared to normal +/+
littermates. Mutant fetuses have less total hemoglobin than do normal
fetuses of the same gestational age. However, when compared to +/+ fetuses
of similar body weight, Ts/+ fetuses have the appropriate amount of total
hemoglobin, suggesting that the apparent anemia observed in mutant fetuses
is most likely the result of delay in growth and development. Changes in
proportions of embryonic hemoglobins during fetal development are similar
in Ts/+ and +/+ fetuses at day 12 and later of gestation. Moreover, adult
hemoglobin is detected in circulating primitive nucleated erythrocytes in
the developmentally retarded Ts/+ mutant fetuses at about the same
chronologic age as their +/+ normal littermates.
Volume 54,
Issue 3,
pp. 673-683,
09/01/1979
Copyright © 1979 by The American Society of Hematology
