Production of fetal antigen-bearing erythrocytes in irradiated adult mice
grafted with fetal liver hematopoietic cells
JP Blanchet, J Samarut and G Mouchiroud
The production of erythrocytes bearing an "immature" antigen (Im+ cells)
and a "fetal" antigen (Ft+ cells) has been studied in irradiated adult mice
grafted either with fetal liver or adult bone marrow cells. The Im+ cells
reach a peak 8-11 days after grafting. Ft+ cells are detected only after
graft of fetal liver cells; the younger the liver, the greater the number.
Since Ft+ cells are rapidly and briefly produced, they could be the progeny
of erythroid-committed precursors, which are particularly numerous among
fetal liver cells. Environmental factors directing the erythropoietic
differentiation towards Ft+ erythrocytes in fetuses or Ft- erythrocytes in
adults are proposed.
Volume 54,
Issue 5,
pp. 1091-1100,
11/01/1979
Copyright © 1979 by The American Society of Hematology
