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Inhibition of platelet function by organic nitrate vasodilators
AI Schafer, RW Alexander and RI Handin
There is evidence that platelet activation in the coronary circulation may
be important in the pathogenesis of myocardial ischemia. Since organic
nitrate vasodilators are commonly used in coronary artery disease, we have
studied the in vitro effects of these drugs on platelet function.
Nitroglycerin, isosorbide dinitrate, and their biotransformation product,
inorganic nitrite, inhibited platelet aggregation with collagen,
epinephrine, arachidonate, and ionophore, and blocked both primary and
secondary aggregation in response to ADP. Nitroglycerin was studied in more
detail. Its inhibitory effect was reversible and not dependent on external
calcium concentration. It inhibited arachidonic acid oxygenation as
measured by the arachidonate- induced oxygen burst and malonaldehyde
production. These effects were not due to an increase in intracellular
cyclic AMP. This unusual generalized inhibition of platelet function by
nitroglycerin possibly contributes to its beneficial effect in myocardial
ischemia in part by attenuating platelet reactivity in the coronary
circulation.
Volume 55,
Issue 4,
pp. 649-654,
04/01/1980
Copyright © 1980 by The American Society of Hematology
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