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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rosove, M. H. Articles by Zighelboim, J. Search for Related Content PubMed PubMed Citation Articles by Rosove, M. H. Articles by Zighelboim, J. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Severe platelet dysfunction in hairy cell leukemia with improvement after splenectomy MH Rosove, F Naeim, S Harwig and J Zighelboim A patient with hairy cell leukemia developed purpura not attributable to thrombocytopenia. We found markedly reduced platelet aggregation responses and malondialdehyde production, decreased serotonin uptake, and depleted dense granule contents. Ultrastructural studies showed that most platelets had few or nor granules. All of the clinical and laboratory studies of platelet function and morphology improved after splenectomy. These findings indicate that qualitative defects in platelet function occurring in hairy cell leukemia may cause clinically important bleeding and that the bleeding diathesis may be ameliorated by splenectomy. Volume 55, Issue 6, pp. 903-906, 06/01/1980 Copyright © 1980 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. CHAMPLIN, R. P. GALE, K. A. FOON, and D. W. GOLDE Chronic Leukemias: Oncogenes, Chromosomes, and Advances in Therapy Ann Intern Med, May 1, 1986; 104(5): 671 - 688. [Abstract] [PDF]

	Copyright © 1980 by American Society of Hematology         Online ISSN: 1528-0020