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Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro--a cooperative work

F Takaku, T Suda, H Mizoguchi, Y Miura, H Uchino, K Nagai, S Kariyone, A Shibata, T Akabane, T Nomura and T Maekawa

Thirty-six patients with aplastic anemia and three with aplastic anemia- PNH syndrome in eight institutes were studied for the presence of peripheral blood mononuclear cells having a suppressive effect on granulocyte-macrophage (G-M) and erythroid colony formation using a uniform protocol. In 11 cases of 29 (38%) and 9 cases of 29 (31%), the presence of mononuclear cells with a suppressive effect on G-M and erythroid colony formation, respectively, was demonstrated. However, the presence of mononuclear cells suppressive both to G-M and erythroid colony formation was demonstrated only in 3 of 19 cases (16%).

Volume 55, Issue 6, pp. 937-943, 06/01/1980
Copyright © 1980 by The American Society of Hematology


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 ANN INTERN MEDHome page
N. I. ABDOU, J. D. VERDIRAME, M. AMARE, and N. L. ABDOU
Heterogeneity of Pathogenetic Mechanisms in Aplastic Anemia: Efficacy of Therapy Based on In-Vitro Results
Ann Intern Med, July 1, 1981; 95(1): 43 - 50.
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  Copyright © 1980 by American Society of Hematology         Online ISSN: 1528-0020