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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kaneko, Y. Articles by Moohr, J. W. Search for Related Content PubMed PubMed Citation Articles by Kaneko, Y. Articles by Moohr, J. W. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  The 14q+ chromosome in pre-B-ALL Y Kaneko, JD Rowley, I Check, D Variakojis and JW Moohr A child who had acute lymphoblastic leukemia (ALL) associated with an 8;14 chromosome translocation and with a pre-B phenotype is described. The leukemic cells were determined to be pre-B-cells on the basis of intracytoplasmic mu-chain immunoglobulin (cIgM+) and the common-ALL antigen, lack of receptors for sheep erythrocytes, and lack of surface immunoglobulin. The 8;14 translocation is frequently found in patients with Burkitt's lymphoma and in most patients with B-cell ALL and is known to carry a poor prognosis. Thus far, no karyotypes have been reported for patients with pre-B-ALL. The present case indicates that a 14q+ chromosome may provide a proliferative advantage not only to cells with a B-cell phenotype, but also to pre-B-cells. The short survival of our patient also suggests that the 14q+ abnormality and the pre-B phenotype may signal a poor prognosis. Volume 56, Issue 5, pp. 782-785, 11/01/1980 Copyright © 1980 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M R Velangi, M M Reid, N Bown, G H Jackson, G P Summerfield, S J Proctor, and P R A Taylor Acute lymphoblastic leukaemia of the L3 subtype in adults in the Northern health region of England 1983-99 J. Clin. Pathol., August 1, 2002; 55(8): 591 - 595. [Abstract] [Full Text] [PDF]

	Copyright © 1980 by American Society of Hematology         Online ISSN: 1528-0020