Sources of variability in antihemophilic factor (factor VIII) procoagulant
titers and precipitating antigen levels among obligate carriers of classic
hemophilia
PK Jones and OD Ratnoff
Chediak et al. have reported that the titer of procoagulant antihemophilic
factor (AHF:C; factor VIII:C) was significantly lower in obligate carriers
of classic hemophilia who were daughters of affected men (paternal
carriers) than in those whose fathers were normal by history (maternal
carriers). In contrast, among 113 obligate carriers of hemophilia, no
significant difference in procoagulant AHF titers was observed between
paternal and maternal carriers. The concentration of AHF-like precipitating
antigens, however, was significantly higher in maternal than in paternal
carriers. This difference may have reflected in part the greater severity
of disease in affected males in the families of maternal carriers.
Volume 57,
Issue 5,
pp. 928-932,
05/01/1981
Copyright © 1981 by The American Society of Hematology
