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FS Ligler, JR Kettman, RG Smith and EP Frenkel
The present study examines the relative amounts of surface immunoglobulin
(Ig) on lymphocytes obtained from 64 patients with chronic lymphocytic
leukemia (CLL) and correlates these findings with the clinical stage of
disease. Since the maturing B cell first expresses surface IgM, followed by
IgD, and subsequently by IgG, IgA, or IgE, the surface Ig phenotype can be
used as a marker of differentiation. Surface Ig was analyzed using the
fluorescence- activated cell sorter under carefully controlled conditions.
The cells from all patients with CLL were monoclonal with respect to light
chain type. Those patients with IgM as the brightest heavy chain class
(suggesting relatively immature B cells) had clinically advanced stages of
CLL, whereas those with a predominance of IgG (suggesting more mature
cells) have a lesser stage of CLL. Thus, the predominant Ig heavy chain
class appears to correlate with clinical stage of CLL and provides a clue
to the potential aggressiveness of the tumor.
This article has been cited by other articles:
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| Copyright © 1983 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
