|
|
 Previous Article | Table of Contents | Next Article 
Ethanol raises prostacyclin in vivo and in vitro
R Landolfi and M Steiner
Moderate doses of ethanol were shown to induce a significant rise in
prostacyclin (PGI2) concentration in cultures of endothelial cells derived
from umbilical veins. Administration of 32 g of ethanol to six volunteers
elevated plasma levels of PGI2 in parallel with those of blood alcohol.
Although not specific for ethanol, this alcohol induced the largest change
in PGI2. Withdrawal of the stimulant alcohol caused prompt reduction of the
elevated prostacyclin to baseline values. The activity of ethanol appears
to be due to a direct stimulation of cyclooxygenase. The release of
[14C]arachidonic acid from prelabeled endothelial cells was decreased by
ethanol. PGE2 production was also enhanced by exposure of endothelial cells
to ethanol. The physiologic significance of these alcohol-induced changes
in PGI2 levels remains to be established.
Volume 64,
Issue 3,
pp. 679-682,
09/01/1984
Copyright © 1984 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
V. Solfrizzi, A. D'Introno, A. M. Colacicco, C. Capurso, A. Del Parigi, G. Baldassarre, P. Scapicchio, E. Scafato, M. Amodio, A. Capurso, et al.
Alcohol consumption, mild cognitive impairment, and progression to dementia
Neurology,
May 22, 2007;
68(21):
1790 - 1799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Espeland, L. Gu, K. H. Masaki, R. D. Langer, L. H. Coker, M. L. Stefanick, J. Ockene, S. R. Rapp, and for the Women's Health Initiative Memory Study
Association between Reported Alcohol Intake and Cognition: Results from the Women's Health Initiative Memory Study
Am. J. Epidemiol.,
February 1, 2005;
161(3):
228 - 238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kalmijn, M. P. J. van Boxtel, M. W. M. Verschuren, J. Jolles, and L. J. Launer
Cigarette Smoking and Alcohol Consumption in Relation to Cognitive Performance in Middle Age
Am. J. Epidemiol.,
November 15, 2002;
156(10):
936 - 944.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Numminen, M. Kobayashi, S. Uchiyama, M. Iwata, Y. Ikeda, A. Riutta, M. Syrjala, R. Kekomaki, and M. Hillbom
EFFECTS OF ALCOHOL AND THE EVENING MEAL ON SHEAR-INDUCED PLATELET AGGREGATION AND URINARY EXCRETION OF PROSTANOIDS
Alcohol Alcohol.,
November 1, 2000;
35(6):
594 - 600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Berger, U. A. Ajani, C. S. Kase, J. M. Gaziano, J. E. Buring, R. J. Glynn, and C. H. Hennekens
Light-to-Moderate Alcohol Consumption and the Risk of Stroke among U.S. Male Physicians
N. Engl. J. Med.,
November 18, 1999;
341(21):
1557 - 1564.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Kiechl, J. Willeit, G. Rungger, G. Egger, F. Oberhollenzer, and E. Bonora
Alcohol Consumption and Atherosclerosis: What Is the Relation? : Prospective Results From the Bruneck Study
Stroke,
May 1, 1998;
29(5):
900 - 907.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. Rich-Edwards, J. E. Manson, C. H. Hennekens, and J. E. Buring
The Primary Prevention of Coronary Heart Disease in Women
N. Engl. J. Med.,
June 29, 1995;
332(26):
1758 - 1766.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Rosenson
Low Levels of High-Density Lipoprotein Cholesterol (Hypoalphalipoproteinemia) An Approach to Management
Arch Intern Med,
July 12, 1993;
153(13):
1528 - 1538.
[Abstract]
[PDF]
|
|
|
|
|
