Busulfan and total body irradiation as antihematopoietic stem cell agents
in the preparation of patients with congenital bone marrow disorders for
allogenic bone marrow transplantation
R Parkman, JM Rappeport, S Hellman, J Lipton, B Smith, R Geha and DG Nathan
The capacity of busulfan and total body irradiation to ablate hematopoietic
stem cells as preparation for the allogeneic bone marrow transplantation of
patients with congenital bone marrow disorders was studied. Fourteen
patients received 18 transplants; busulfan was used in the preparatory
regimen of eight transplants and total body irradiation in the regimens of
six transplants. Sustained hematopoietic ablation was achieved in six of
eight patients prepared with busulfan and in all six patients prepared with
total body irradiation. Three patients prepared with total body irradiation
died with idiopathic interstitial pneumonitis, whereas no patients
receiving busulfan developed interstitial pneumonitis. The optimal
antihematopoietic stem cell agent to be used for the preparation of
patients with congenital bone marrow disorder for bone marrow
transplantation is not certain.
Volume 64,
Issue 4,
pp. 852-857,
10/01/1984
Copyright © 1984 by The American Society of Hematology
