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Therapeutic experience on 934 adults with idiopathic thrombocytopenic
purpura: Multicentric Trial of the Cooperative Latin American group on
Hemostasis and Thrombosis
J Pizzuto and R Ambriz
In order to analyze the usefulness of different types of treatment in
relation to the interval since the onset of idiopathic thrombocytopenic
purpura (ITP), a collaborative study of 934 adult patients was undertaken.
Prednisone was administered to 818 patients, and 32% of them achieved
prolonged complete remission (PCR). However, only 14% of patients who had
ITP for more than six months achieved a prednisone- induced PCR (P less
than .01). Splenectomy was done in 399 patients, and 65% of them achieved
PCR; the remission rate did not vary with the interval since the onset of
ITP. Of 120 patients with chronic ITP that was refractory to
corticosteroids and splenectomy, 91 received either azathioprine or
cyclophosphamide; 21% of them achieved PCR and 55% had a favorable
response. None of 19 patients treated with vincristine and only one of ten
patients treated with vinblastine-loaded platelets achieved PCR.
Volume 64,
Issue 6,
pp. 1179-1183,
12/01/1984
Copyright © 1984 by The American Society of Hematology
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