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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kitchingman, G. R. Articles by Stass, S. Search for Related Content PubMed PubMed Citation Articles by Kitchingman, G. R. Articles by Stass, S. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Rearrangement of immunoglobulin heavy chain genes in T cell acute lymphoblastic leukemia GR Kitchingman, U Rovigatti, AM Mauer, S Melvin, SB Murphy and S Stass We studied the arrangement of the immunoglobulin heavy chain genes by Southern blot analysis of DNA freshly obtained from marrow blast cells of 14 children with T cell acute lymphoblastic leukemia (T-ALL) using probes to the C mu and JH gene segments: At least one of the C mu-gene alleles was rearranged in three cases. In two of these, one C mu gene had the germ-line configuration and one was rearranged, whereas both alleles were rearranged in the third case. In one case, a rearranged heavy chain gene hybridized to the C mu-region probe, but not to the JH probe, indicating that the entire JH region had been deleted. These results demonstrate that immunoglobulin heavy chain gene rearrangements are not restricted to B lineage lymphoproliferative diseases in humans. Volume 65, Issue 3, pp. 725-729, 03/01/1985 Copyright © 1985 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Yao, S. A. Rich, and E. Schneider Validation of Sixteen Leukemia and Lymphoma Cell Lines as Controls for Molecular Gene Rearrangement Assays Clin. Chem., August 1, 2002; 48(8): 1344 - 1351. [Abstract] [Full Text] [PDF] S M Kröber, A Greschniok, E Kaiserling, and H-P Horny Acute lymphoblastic leukaemia: correlation between morphological/immunohistochemical and molecular biological findings in bone marrow biopsy specimens Mol. Pathol., April 1, 2000; 53(2): 83 - 87. [Abstract] [Full Text] M. J. Pongers-Willemse, A. W. Langerak, W. A. Harts, A. J.M. Wijkhuijs, E. R. van Wering, and J. J.M. van Dongen Ig Heavy Chain Gene Rearrangements in T-Cell Acute Lymphoblastic Leukemia Exhibit Predominant DH6-19 and DH7-27 Gene Usage, Can Result in Complete V-D-J Rearrangements, and Are Rare in T-Cell Receptor alpha beta Lineage Blood, June 15, 1999; 93(12): 4079 - 4085. [Abstract] [Full Text] [PDF] M. Greaves Differentiation-linked leukemogenesis in lymphocytes Science, November 7, 1986; 234(4777): 697 - 704. [Abstract] [PDF]

	Copyright © 1985 by American Society of Hematology         Online ISSN: 1528-0020